Speakers

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Carla Gauss
Senior Application Scientist
Nanome

Day One

Wednesday 26th May 2021

5:00 pm | Virtual Reality in SBDD: Exploring Complexes of the IMiDs and DDB1-CRBN E3 Ubiquitin Ligase in Nanome

James Vasta
Senior Research Scientist
Promega

Day One

Wednesday 26th May 2021

10:15 am | A Best In-Class Method to Quantify Target Engagement and Cellular Entry for PROTACs

Toren Finkel
Chief Scientific Officer, Generian & Professor of Medicine and Director
Aging Institute, University of Pittsburgh/UPMC

Day Two

Thursday 27th May 2021

10:15 am | Drugging Transcription Factors and Kinases by Preventing E3- Dependent Degradation

10:30 am | Live Panel Q&A – Ask the Speakers Your Burning Questions!

Andrew Zhang
Team Leader
AstraZeneca

Fiona Pachl
Senior Scientist
AstraZeneca

Meha Singh
Senior Scientist
AstraZeneca

Ryan Potts
Executive Director & Head of IPP
Amgen

Day One

Wednesday 26th May 2021

3:50 pm | Tissue-Specific Ubiquitin Ligases for Targeted Protein Degradation

4:15 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

Miklos Bekes
Senior Research Investigator & Group Leader in Platform Biology
Arvinas

Day One

Wednesday 26th May 2021

10:40 am | Live Panel Q&A – Ask the Speakers Your Burning Questions!

9:50 am | Arvinas’ PROTAC® Discovery Engine: Selecting & Employing E3s for PROTACs

Katelyn Cassidy
Senior Scientist
AstraZeneca

Rick Davies
Associate Director
AstraZeneca Pharmaceuticals

Day One

Wednesday 26th May 2021

6:30 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

5:40 pm | Benchmarking Selection & Design of New E3 Ligases for PROTACS

Day Two

Thursday 27th May 2021

12:00 pm | PANEL DISCUSSION: Exploring the Therapeutic Value of Targeting E3 Ubiquitin Ligases

Daniel Nomura
Professor of Chemistry, University of California
Berkeley

Day One

Wednesday 26th May 2021

10:40 am | Live Panel Q&A – Ask the Speakers Your Burning Questions!

9:00 am | Reviewing & Rethinking Ligase Targeting Drug Development

Joe Patel
Senior Director
C4 Therapeutics

Day One

Wednesday 26th May 2021

4:15 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

3:00 pm | Computational Methods for Degrader Ternary Complex Prediction using HDX Data

Nico Zinn
Group Leader Mass Spectrometry
Cellzome

Alex Bullock
Associate Professor, University of Oxford
Centre for Medicines Discovery

Day One

Wednesday 26th May 2021

1:40 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

12:00 pm | Expanding the E3 Space for PROTAC Development

Xiaoran Han
Director of Discovery Medicine
Cullgen Inc

Day Two

Thursday 27th May 2021

12:00 pm | PANEL DISCUSSION: Exploring the Therapeutic Value of Targeting E3 Ubiquitin Ligases

Yue Xiong
CSO
Cullgen Inc

Day Two

Thursday 27th May 2021

3:20 pm | CRL E3 Ligases: From Catalytic Mechanisms, Assembly to Targeted Protein Degradation

4:10 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

Katherine Donovan
Senior Scientist
Dana-Faber Cancer Institute

Day One

Wednesday 26th May 2021

3:25 pm | Mapping the Degradable Kinome

4:15 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

Radosław Nowak
Scientist, Cancer Biology
Dana-Farber Cancer Institute

Day Two

Thursday 27th May 2021

4:10 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

2:55 pm | Structure Based Design of E3 Targeted Protein Degraders

Nicolas Thomä
Senior Group Leader
Friedrich Miescher Institute for Biomedical Research in Basel

Day Two

Thursday 27th May 2021

4:10 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

2:30 pm | What Makes Two Proteins Stick: Dissecting E3’s Contribution to Molecular Glue Action

Markus Queisser
Scientific Leader
GlaxoSmithKline

Simona Polo
Professor
IFOM, the FIRC Institute for Molecular Oncology & DIPO, Department of Oncology and Hemato-oncology, University of Milan

Day Two

Thursday 27th May 2021

9:25 am | Molecular Mechanisms of Small Molecule-mediated NEDD4 Targeting

10:30 am | Live Panel Q&A – Ask the Speakers Your Burning Questions!

Chris De Savi
Vice President, Head of Drug Discovery
Kymera

Day One

Wednesday 26th May 2021

10:40 am | Live Panel Q&A – Ask the Speakers Your Burning Questions!

9:25 am | Discovery of Potent & Selective IRAK4 & STAT3 Targeted Protein Degraders for Inflammation & Oncology Indications

Ingo Hartung
Director Medicinal Chemistry
Merck KGaA

Day Two

Thursday 27th May 2021

4:10 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

10:30 am | Live Panel Q&A – Ask the Speakers Your Burning Questions!

8:30 am | Chair’s Opening Remarks

Roman Erdmann
Senior Scientist
Merck & Co., Inc

Day Two

Thursday 27th May 2021

4:10 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

3:45 pm | From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

Benika Pinch
Principal Scientist
Novartis Institutes for Biomed Research, Inc

Day One

Wednesday 26th May 2021

1:40 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

1:15 pm | A Strategy to Assess the Cellular Activity of E3 Ligases Against Neo-Substrates Using Electrophilic Probes

Claudio Thoma
Senior Principal Scientist
Novartis Institutes for Biomed Research, Inc

Day Two

Thursday 27th May 2021

12:00 pm | PANEL DISCUSSION: Exploring the Therapeutic Value of Targeting E3 Ubiquitin Ligases

Jeff McKenna
Associate Director, Global Discovery Chemistry
Novartis Institutes for BioMedical Research

Day One

Wednesday 26th May 2021

10:40 am | Live Panel Q&A – Ask the Speakers Your Burning Questions!

6:30 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

4:15 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

1:40 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

8:30 am | Registration & Chair’s Opening Remarks

Benedict Cross
Chief Technology Officer
PhoreMost Ltd

Day One

Wednesday 26th May 2021

1:40 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

12:25 pm | Unlocking the Ligandable Space with Ligase-centric PROTEINi Screening

Kumar Suresh
Senior Director R&D
Progenra Inc

Day One

Wednesday 26th May 2021

6:30 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

6:05 pm | Effectively Harnessing E3’s for Rapid PROTAC Development

Pengyu Yang
Associate Director
Plexium

Day Two

Thursday 27th May 2021

12:00 pm | PANEL DISCUSSION: Exploring the Therapeutic Value of Targeting E3 Ubiquitin Ligases

Dalia Barsyte-Lovejoy
Principal Investigator
Structural Genomics Consortium

Day One

Wednesday 26th May 2021

12:50 pm | Discovery of Novel Ligands & Probes for E3 Ligases

1:40 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

Jennifer Venable
Senior Scientific Director
The Janssen Pharmaceutical Companies of Johnson & Johnson

Day Two

Thursday 27th May 2021

12:00 pm | PANEL DISCUSSION: Exploring the Therapeutic Value of Targeting E3 Ubiquitin Ligases

Rebecca Feltham
Laboratory Head
The Walter and Eliza Hall Institute of Medical Research

Day One

Wednesday 26th May 2021

5:15 pm | New Insights into PROTAC-based Target Validation Strategies

6:30 pm | Live Panel Q&A – Ask the Speakers Your Burning Questions!

Nicholas Brown
Assistant Professor
University of North Carolina

Day Two

Thursday 27th May 2021

9:00 am | Activation of the RING E3 Anaphase-Promoting Complex/ Cyclosome (APC/C)

Danny Huang
Senior Group Leader & Professor of Cancer Structural Biology
University of Glasgow

Day Two

Thursday 27th May 2021

10:30 am | Live Panel Q&A – Ask the Speakers Your Burning Questions!

9:50 am | Targeting the Ubiquitin Ligase Activity of MDM2