Radoslav Enchev

Company: The Francis Crick Institute

Job title: Group Leader Visual Biochemistry Laboratory

Seminars:

Spearheading Time-Resolved Cryo-EM to Integrate Structural Dynamics Studies into Ligase-Targeted Drug Discovery 2:00 pm

Unlocking the therapeutic potential of ubiquitin ligase targeting drugs, in particular in the context of targeted protein degradation, involves a deep understanding of ligase drug and the ternary ligase-drug-target interactions. However traditional profiling of ternary complexes formation is confronted by many bottlenecks including challenges to sample preparation for structural studies due to heterogeneity and conformational…Read more

day: Pre-Conference Day