2023 Workshop Day
Tuesday April 11, 2023
All times in EDT
9.00-11.00
A Whole New Modality - Delving into E3 Ligase Inhibition
Attend this workshop to:
- Understand an E3 ligase inhibitor mode of action to effectively develop a candidate to target for inhibition
- Uncover the advantages of ligase inhibition over classic degradation as a potential alternative modality through insights gained using computational approaches
- Explore hurdles to ligase inhibition and the potential drawbacks in the context of off-target effects with the story of Nurix's CBL program
Workshop Leader:
Sumit Prakash
Associate Director
Nurix Therapeutics
Xevi Fradera
Senior Principal Scientist
Blueprint Medicines
11.00 am Morning Networking Break
11.30-1.30
Exploring Electrophilic Ligands for Efficient Ligase Discovery
Attend this workshop to:
- Discover how the rational design of covalent ligands is still faced with particular challenges
- Uncover the properties of electrophilic ligands that make them advantageous ‘probes’ for targeted ligase discovery
- Review the available technical solutions for performing docking calculations with covalent ligands
Workshop Leader:
Nathaniel Henning
Scientist - Chemical Biology
Vincintas Therapeutics
1.30 pm Afternoon Break
2.30-4.30
Integrating Computational Approaches to Enhance Early Ligase & Ligand Discovery
Attend this workshop to:
- Acquire an expert overview of some of the most exciting, novel computational tools currently in development, and now readily available to turbocharge your ligase functional and structural insights
- Leverage the insights from computational experts who are harnessing machine learning and AI approaches, to predict ligase and ligand complex conformations
- Gain knowledge of the novel tools and assays that can validate these computational methods, including crystallography images to visualize the ternary complex
Workshop Leaders:
Li Xiao
Computational Scientist
Merck
Song Yang
Research Investigator
Arvinas
