Wei Zhang

Wei Zhang

Company: University of Guelph

Job title: Assistant Professor


Targeted Protein Degradation Using Ubiquitin Variant Induced Proximity 2:00 pm

We devised structure-based combinatorial protein design and engineering strategies to develop Ub variant (UbV) activators for human E3 ligases We assembled a UbV induced proximity (UbVIP) library for targeted protein degradation We identified UbVIPs that successfully induced intracellular degradation of nucleus substratesRead more

day: Focus Day

Roundtable Session: Tissue & Cell Selectivity – Highlighting the Potential for Selective E3 Targeting 2:30 pm

As expression and profiling data begin to shed light on the distribution of E3’s across cell and tissue types, it is becoming evident that such data may provide promising insights to aid the development of tissue E3 specific targeting, within a therapeutic context. What is the difficulty of selectively targeting E3’s in tumor cells and…Read more

day: Day One

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