Sharon Shechter

Sharon Shechter

Company: Roivant Sciences

Job title: Director of Platform Integration

Seminars:

Live Panel Q&A – Ask the Speakers Your Burning Questions 2:50 pm

Read more

day: Day Two

Ternary Complex Structure Prediction by Combining Molecular Simulations with Hydrogen Deuterium Exchange 2:00 pm

Reviewing how the formation of the POI-degrader-E3 ternary complex is central to the targeted protein degradation process. Using a single conformation (e.g., x-ray crystal) neglects the complex dynamic nature of the non-native induced proximity complex Combining experimental biophysical data (HDX-MS) with molecular dynamics (MD) simulations can significantly improve ternary complex structure prediction, reaching atomic resolution…Read more

day: Day Two

Panel Discussion: Translational Role of E3 Ligases in Therapeutics for Disease 12:00 pm

As covalent targets successfully progress through clinical phases, and molecular glues propose it is critical that we consider the optimum safety, translation, and development of effective therapeutics. From tissue and cell specificity, preclinical translation and toxicity effects, discussion about the all-important translation of this promising therapeutic begins here. What are the likely viable therapeutic applications…Read more

day: Day Two

© Copyright 2022 Hanson Wade | Design and site by Event Engine | Hanson Wade Limited is registered in England & Wales, number 06752216.
Registered Office: Suite A, 6 Honduras Street, London EC1Y 0TH.