Sarath Ramachandran

Sarath Ramachandran

Company: Centre for Targeted Protein Degradation, University of Dundee

Job title: Senior Drug Discovery Scientist

Seminars:

Structure-Guided Design of Small Molecule Covalently targeting SH2 Domain of the E3 Ligase SOCS2 12:30 pm

• We report structure guided design and development of potent phosphotyrosine-based covalent binders targeting the SH2 domain of SOCS2 • The covalent binder is structurally and biophysically characterised • Cellular target engagement assay to demonstrate permeability and potency of the binderRead more

day: Focus Day

Live Panel Q&A – Ask the Speakers Your Burning Questions 2:50 pm

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day: Day Two

Development of Chemical Probes & E3 Ligase Recruiting PROTAC Handles Targeting SOCS2 12:30 pm

The structure of guided design and development of potent covalent and non-covalent binders targeting SH2 domain of SOCS2 The evaluation of several phosphate masking prodrugs to demonstrate cellular SOCS2 engagement by the binders Differential cellular expression profiles of SOCS proteins provide an opportunity to utilize SOCS recruiting PROTACs to tune tissue/disease specific degradation of target…Read more

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