Matt Clifton

Matt Clifton

Company: Novartis institutes for Biomedical Research

Job title: Director Structural & Biophysical Chemistry

Seminars:

Live Panel Q&A – Ask the Speakers Your Burning Questions 2:50 pm

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day: Day Two

Chair’s Closing Remarks 3:00 pm

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day: Focus Day

Chair’s Opening Remarks 9:50 am

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day: Focus Day

Driving Drug Discovery by Accelerated Target Degradation 2:25 pm

The Imids serve as a molecular glue that subverts the functional E3 ubiquitin ligase complex allowing it to bind neosubstrates and subject them to ubiquitination and subsequent degradation: to exploit this mechanism an expansive library of Imids and related CRBN binders was created This chemical atlas has been screened using a mammalian two hybrid system…Read more

day: Day Two

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