Matt Clifton
Company: Novartis institutes for Biomedical Research
Job title: Director Structural & Biophysical Chemistry
Seminars:
Live Panel Q&A – Ask the Speakers Your Burning Questions 2:50 pm
day: Day Two
Chair’s Closing Remarks 3:00 pm
day: Focus Day
Chair’s Opening Remarks 9:50 am
day: Focus Day
Driving Drug Discovery by Accelerated Target Degradation 2:25 pm
The Imids serve as a molecular glue that subverts the functional E3 ubiquitin ligase complex allowing it to bind neosubstrates and subject them to ubiquitination and subsequent degradation: to exploit this mechanism an expansive library of Imids and related CRBN binders was created This chemical atlas has been screened using a mammalian two hybrid system…Read more
day: Day Two